Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in Mice

    March 2023
    Yan Teng, Anna Sun, Xiaochen Pan, Guan Yang, Leilei Yang, Ming‐Rong Wang, Xiao Yang
    Image of study
    TLDR Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.
    The study investigates the genetic basis of esophageal tumorigenesis by examining the effects of deleting the Smad4 and PTEN genes in mice. The simultaneous inactivation of these genes led to accelerated hair loss, skin tumor formation, and spontaneous forestomach carcinogenesis, with all tumors being invasive squamous cell carcinomas (SCCs) within the first 2 months of age. Some SCC lesions were accompanied by adenocarcinomas in adjacent submucosa regions. The rapid tumor progression was linked to increased epithelial proliferation and decreased expression of cell cycle inhibitors (p27, p21, p16) along with overexpression of cyclin D1. The findings highlight the synergistic role of Smad4 and PTEN in suppressing forestomach tumorigenesis by inducing cell cycle inhibitors.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 7 results

      community What's your option on complementary treatment

      in Product  3 upvotes 1 year ago
      The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

      community My Theory Of Androgenic Alopecia

      in Research/Science  21 upvotes 2 months ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

      community Creatine's effect on Hair Loss and DHT

      in Research/Science  100 upvotes 1 year ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community Should I take creatine if Im on fin?

      in Finasteride/Dutasteride  9 upvotes 7 months ago
      Creatine is unlikely to worsen hair loss for those on finasteride, with no strong scientific evidence linking it to increased hair loss. Many users report no negative effects on hair while using creatine.

    Similar Research

    5 / 1000+ results