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GlossaryPTEN

gene that regulates cell growth and prevents tumor formation

PTEN (Phosphatase and Tensin Homolog) is a gene that produces an enzyme involved in regulating cell growth by deactivating certain signaling pathways. Mutations in the PTEN gene can lead to uncontrolled cell division and are associated with various cancers and conditions like Cowden syndrome, which can also affect hair growth and lead to alopecia.

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research BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy

24 citations, September 2019 in “Experimental cell research”

BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.

research Activation of Androgen Receptor Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

23 citations, December 2013 in “Molecular cancer therapeutics”

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

research PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells

22 citations, June 2017 in “Stem cell reports”

PTEN helps control the number and health of skin stem cells by working with the protein BMAL1.

research Promoting Axonal Regeneration Through Exosomes: An Update of Recent Findings on Exosomal PTEN and mTOR Modifiers

14 citations, October 2018 in “Brain Research Bulletin”

Exosomes help nerve fibers grow by affecting specific cell signaling pathways.

research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury

6 citations, February 2022 in “The journal of neuroscience/The Journal of neuroscience”

Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.