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GlossaryPTEN

gene that regulates cell growth and prevents tumor formation

PTEN (Phosphatase and Tensin Homolog) is a gene that produces an enzyme involved in regulating cell growth by deactivating certain signaling pathways. Mutations in the PTEN gene can lead to uncontrolled cell division and are associated with various cancers and conditions like Cowden syndrome, which can also affect hair growth and lead to alopecia.

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research BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy

24 citations , September 2019 in “Experimental cell research”

BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.

research Activation of Androgen Receptor Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

23 citations , December 2013 in “Molecular cancer therapeutics”

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

1 citations , May 2022 in “Frontiers in Pharmacology”

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

research Inducible Beta-Catenin Activation and PTEN Inactivation Elicit Follicular Tumors, Not Papillomas: A Potential Paradigm for Trichilemmomas in Cowden's Disease

January 2017 in “Enlighten: Publications (The University of Glasgow)”

Activating β-catenin and inactivating PTEN cause follicular tumors, not papillomas, similar to those in Cowden’s Disease.

Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus

research Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus

April 2023 in “Journal of Investigative Dermatology”

PTEN was identified as a specific marker for the skin disease cutaneous lupus erythematosus, and it helps increase the expression of harmful type I interferons.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.