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    Glossary PTEN

    gene that regulates cell growth and prevents tumor formation

    PTEN (Phosphatase and Tensin Homolog) is a gene that produces an enzyme involved in regulating cell growth by deactivating certain signaling pathways. Mutations in the PTEN gene can lead to uncontrolled cell division and are associated with various cancers and conditions like Cowden syndrome, which can also affect hair growth and lead to alopecia.

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    Research 30 of 488

    1. BMP2-mediated PTEN enhancement promotes differentiation of hair follicle stem cells by inducing autophagy Experimental cell research · 2019 · 24 citations
    2. Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation Molecular cancer therapeutics · 2013 · 23 citations
    3. PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells Stem cell reports · 2017 · 22 citations
    4. Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids Burns & Trauma · 2024 · 17 citations
    5. Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers Brain Research Bulletin · 2018 · 14 citations
    6. Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury 2022 · 6 citations
    7. The crosstalk between PTEN ‐induced kinase 1‐mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata Experimental Dermatology · 2023 · 6 citations
    8. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells Annals of Medicine · 2025
    9. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    10. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    11. 1616 Cross-comparison of inflammatory skin disease transcriptomics identifies PTEN as a pathogenic disease classifier in cutaneous lupus erythematosus Journal of Investigative Dermatology · 2023
    12. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    13. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    14. Inducible ß-Catenin Activation and PTEN Inactivation Elicit Follicular Tumours, Not Papillomas: A Potential Paradigm for Trichilemmomas in Cowden’s Disease Enlighten: Publications (The University of Glasgow) · 2017
    15. 1330 The possible role of PTEN-induced kinase 1-mediated mitophagy by regulating inflammasome activation in the pathogenesis of alopecia areata 2023
    16. Inducible cre-mediated N-ras activation and PTEN inactivation in transgenic mouse melanocytes requires keratinocyte hyperplasia to elicit a melanocyte pathology Enlighten: Publications (The University of Glasgow) · 2005
    17. 527 PTEN is a master driver of healing inhibition in venous leg ulcers by targeting immune response, angiogenesis and lymphangiogenesis Journal of Investigative Dermatology · 2024
    18. A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice Journal of Biological Chemistry · 2022 · 9 citations
    19. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006 · 176 citations
    20. Stem cell quiescence acts as a tumour suppressor in squamous tumours Nature Cell Biology · 2013 · 66 citations
    21. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    22. <i>Pten</i> loss in Lgr5<sup>+</sup> hair follicle stem cells promotes SCC development Theranostics · 2019 · 24 citations
    23. The molecular pathogenesis of Trichilemmal carcinoma BMC Cancer · 2020 · 19 citations
    24. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma Experimental Dermatology · 2016 · 8 citations
    25. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues The Journal of Physiology · 2015 · 8 citations
    26. Hair(y) Matters in Melanoma Biology Trends in molecular medicine · 2020 · 7 citations
    27. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters Experimental Dermatology · 2016 · 6 citations
    28. Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1 Frontiers in Pharmacology · 2022 · 1 citations
    29. Clinical-Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome (PCOS) Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment Research Square (Research Square) · 2024
    30. Dual aspects of B cells in tumor immunity; B cells are capable of positive and negative regulation for tumor immunity against B16 melanoma Journal of Dermatological Science · 2017