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GlossaryPTEN (PTEN Gene)

gene that regulates cell growth and prevents tumor formation

PTEN (Phosphatase and Tensin Homolog) is a gene that produces an enzyme involved in regulating cell growth by deactivating certain signaling pathways. Mutations in the PTEN gene can lead to uncontrolled cell division and are associated with various cancers and conditions like Cowden syndrome, which can also affect hair growth and lead to alopecia.

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research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury

6 citations , February 2022 in “The journal of neuroscience/The Journal of neuroscience”

Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.

research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in Mice

March 2023

Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.

research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse

March 2023

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

36 citations , January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

research Pre-Clinical Non-Viral Vectors Exploited for In Vivo CRISPR/Cas9 Gene Editing: An Overview

23 citations , January 2022 in “Biomaterials Science”

Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.