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Glossary Tumor Suppressor Gene

regulates cell growth by preventing uncontrolled cell division

A tumor suppressor gene is a type of gene that helps regulate cell growth by preventing cells from dividing too quickly or in an uncontrolled way. When these genes are mutated or inactivated, it can lead to the development of cancer because the normal checks on cell division are lost. Examples include the TP53 gene, which produces a protein that can trigger cell death if DNA damage is detected, thereby preventing the propagation of potentially cancerous cells.

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Research

5 / 1000+ results

research The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters

6 citations , May 2016 in “Experimental Dermatology”

This study by Flores and colleagues found that the type of tumor that develops in a specific subset of epidermal stem cells is influenced by which tumor suppressor gene is deleted.

research 410 NON-INVASIVE DIAGNOSIS OF PROSTATE CANCER FROM BODY FLUIDS USING A PANEL OF TUMOR SUPPRESSOR GENES

March 2011 in “European Urology Supplements”

Blood tests for tumor cells could improve prostate cancer diagnosis and treatment; hair loss severity linked to a gene affecting prostate conditions.

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

72 citations , November 2012 in “PloS one”

This study found that dysregulation of the folliculin-p0071 interaction may lead to changes in cell adhesion and signaling, contributing to conditions like emphysema and renal cell carcinoma.

research Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

153 citations , June 2015 in “GenomeBiology.com”

This study found that both genome-wide screening methods identified the VTRNA2-1 epiallele as highly responsive to environmental influences, suggesting a link between early embryonic environment, epigenetic changes, and human disease.

research Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

81 citations , November 2012 in “Journal of the National Cancer Institute”

This study found that FLCN deficiency in mice muscles led to increased mitochondrial biogenesis and a metabolic shift towards oxidative phosphorylation, with a similar advantage observed in FLCN-null kidney cancer cells.

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Community Join

5 / 57 results

community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 5 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 1 year ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

community Testosterone and hair loss seeming irrelevance

82 upvotes 3 years ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

233 upvotes 10 months ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

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Learn

3 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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Experts

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22
Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi