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Glossary oncogene

gene that can cause cancer when mutated or overexpressed

An oncogene is a type of gene that, when mutated or expressed at high levels, can transform a normal cell into a cancerous one. In simpler terms, it's like a switch that, when turned on incorrectly, can lead to uncontrolled cell growth and potentially cancer. For professionals, oncogenes are often derived from proto-oncogenes, which are normal genes involved in cell growth and division, but become harmful when altered.

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research Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice

150 citations , June 1999 in “Oncogene”

research Molecular mechanisms of viral oncogenesis in humans

141 citations , August 2018 in “Nature Reviews Microbiology”

This review discusses the molecular mechanisms by which oncogenic viruses contribute to cancer development through manipulation of host cellular functions and highlights the need for further research into virus-associated cancers, reporting no new results.

research A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

67 citations , November 2019 in “Nature Communications”

This study demonstrated that a c-Kit-CreER-driven mouse model confirms melanocyte stem cells as a genuine source of melanoma, paralleling human melanoma in heterogeneity and gene signatures.

research Oncogenic senescence: a multi-functional perspective

32 citations , February 2017 in “Oncotarget”

This workshop review discusses the dual role of cellular senescence in cancer, highlighting both its anticancer effects and pro-tumorigenic potential, while reporting no new research results.

research Hair follicle regeneration suppresses Ras-driven oncogenic growth

17 citations , September 2019 in “Journal of Cell Biology”

This study found that despite carrying an activating Hras mutation, hair follicle stem cells integrate into normal skin without causing tumors, unlike similar mutations in the epidermis, suggesting unique tumor-suppressing mechanisms in hair follicles.

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