The E6/E7 Oncogenes of Human Papillomavirus and Estradiol Regulate Hedgehog Signaling Activity in a Murine Model of Cervical Cancer

May 2019 in “ Experimental Cell Research ”

Verónica Rojo-León, Celina García, C. Valencia, M.D Méndez, Christopher D. Wood, Luis Covarrubias

estradiol hedgehog signaling itraconazole HeLa cells cervical epithelium dysplasia ITC

Studysummary This study found that Hedgehog signaling likely contributes to cervical carcinogenesis, and while itraconazole reduced growth in mice, it did so through pathways other than inhibiting Hedgehog signaling.

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