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GlossaryOncogenic Mutations

changes in DNA that can lead to cancer

Oncogenic mutations, also known as cancer-causing mutations, are changes in the DNA that can transform a normal cell into a cancerous one. These mutations often occur in genes that regulate cell growth, division, and death, such as oncogenes and tumor suppressor genes, leading to uncontrolled cell proliferation and tumor formation.

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Oncogenic Ras Mutation Induces Spatiotemporally Specific Tissue Deformation Through Converting Fluctuated Into Sustained ERK Activation

research Oncogenic Ras Mutation Induces Spatiotemporally Specific Tissue Deformation Through Converting Fluctuated Into Sustained ERK Activation

July 2022 in “Journal of Investigative Dermatology”

A specific mutation in Kras causes abnormal tissue changes by making a cell signal continuously active, which disrupts normal cell coordination.

research Clonal Analysis of Stem Cells in Differentiation and Disease

11 citations, July 2016 in “Current Opinion in Cell Biology”

New techniques have enhanced our understanding of how stem cells function and the role of mutations in aging tissues, which may influence future cancer therapies.

research Plasticity of Differentiated Cells in Wound Repair and Tumorigenesis, Part II: Skin and Intestine

40 citations, August 2018 in “Disease Models & Mechanisms”

Mature cells can re-enter the cell cycle and potentially lead to cancer.

research Mommy, Where Do Tumors Come From? The Origins of Basal Cell Carcinomas

16 citations, May 2011 in “The Journal of clinical investigation/The journal of clinical investigation”

Some skin tumors may start from hair follicle stem cells.

research Skin Stem Cells: At The Frontier Between The Laboratory And Clinical Practice. Part 1: Epidermal Stem Cells

2 citations, November 2015 in “Actas Dermo-Sifiliográficas”

Epidermal stem cells show promise for future dermatology treatments due to ongoing advancements.

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TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

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