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    Glossary Oncogenic Mutations

    changes in DNA that can lead to cancer

    Oncogenic mutations, also known as cancer-causing mutations, are changes in the DNA that can transform a normal cell into a cancerous one. These mutations often occur in genes that regulate cell growth, division, and death, such as oncogenes and tumor suppressor genes, leading to uncontrolled cell proliferation and tumor formation.

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    1. LB1011 Oncogenic ras mutation induces spatiotemporally specific tissue deformation through converting fluctuated into sustained ERK activation Journal of Investigative Dermatology · 2022
    2. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation bioRxiv (Cold Spring Harbor Laboratory) · 2022
    3. Expanding phenotype of hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis caused by FAM111B mutations: Report of an additional family raising the question of cancer predisposition and a short review of early-onset poikiloderma JAAD case reports · 2017 · 23 citations
    4. Author response: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma 2021
    5. The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development The EMBO Journal · 2007 · 125 citations
    6. Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine Disease Models & Mechanisms · 2018 · 40 citations
    7. Mommy — where do tumors come from? 2011 · 16 citations
    8. Clonal analysis of stem cells in differentiation and disease Current Opinion in Cell Biology · 2016 · 11 citations
    9. Skin Stem Cells: At the Frontier Between the Laboratory and Clinical Practice. Part 1: Epidermal Stem Cells Actas Dermo-Sifiliográficas · 2015 · 2 citations
    10. The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome Frontiers in cell and developmental biology · 2023
    11. Hair(y) Matters in Melanoma Biology Trends in molecular medicine · 2020 · 7 citations
    12. Author response: Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes 2020
    13. Decision letter: Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes 2020
    14. Hair follicle regeneration suppresses Ras-driven oncogenic growth Journal of Cell Biology · 2019 · 17 citations
    15. Somatic Mutations in Normal Tissues: New Perspectives on Early Carcinogenesis Annual Review of Cancer Biology · 2023 · 13 citations
    16. Author response: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium 2020
    17. 0748 Synergy of TP53 and non-canonical sonic hedgehog pathway in the development of complex basal cell carcinoma Journal of Investigative Dermatology · 2025
    18. Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermis<i>in vivo</i> bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    19. Acute sensitivity of the oral mucosa to oncogenic <i>K‐ras</i> Journal of pathology · 2011 · 12 citations
    20. Decision letter: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma 2021
    21. 131 Mutational landscape of extramammary Paget disease Journal of Investigative Dermatology · 2018
    22. Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development Biology Direct · 2016 · 19 citations
    23. Abstract 4385: Live-imaging the interface between homeostasis and cancer initiation Cancer research · 2016
    24. Identification and characterization of Birt–Hogg–Dubé associated renal carcinoma The Journal of Pathology · 2007 · 50 citations
    25. Proliferation, but Not Apoptosis, Is Associated with Distinct β-Catenin Expression Patterns in Non-Small-Cell Lung Carcinomas ˜The œAmerican journal of pathology · 2002 · 42 citations
    26. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters Experimental Dermatology · 2016 · 6 citations
    27. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    28. Targeting the Warburg Effect in Anaplastic Thyroid Carcinoma: Metabolic Vulnerabilities and Therapeutic Opportunities International Journal of Molecular Sciences · 2026
    29. PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands Journal of Experimental & Clinical Cancer Research · 2025 · 7 citations
    30. Intestinal Stem Cell Imaging in Colorectal Cancer Screening Journal of Stem Cells and Regenerative Medicine · 2013 · 3 citations