Hair Growth-Promoting Effect of Recombinant Human Sonic Hedgehog Proteins

December 2019 in “ Biomedical dermatology ”

Shin-Hye Yu, Yujin Kim, Narae Jung, Jung Wook Hwang, Nayoung Kim, Jong-Cheon Ha, Mi Jin Kim, Young-Jun Lee, Yong‐Soo Choi, Kyutae Han, Chun-Hyung Kim

recombinant human sonic hedgehog proteins Shh signaling pathways hair growth-related gene expression human dermal papilla cells hair density hair length Shh proteins

TLDR Sonic hedgehog proteins may help grow hair.

The study by Yu et al. investigated the effects of recombinant human sonic hedgehog (Shh) proteins on hair growth. They successfully overexpressed and purified Shh proteins, which were shown to activate Shh signaling pathways and induce hair growth-related gene expression in human dermal papilla cells. Additionally, the application of Shh proteins to the skin of mice increased hair density and length. The results suggest that Shh proteins have the potential to be used as a treatment for promoting hair growth. However, the document did not provide the number of mice or cells used in the experiments, which is important for assessing the strength of the study.

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research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

138 citations , June 2012 in “Genes & Development”

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

113 citations , October 2005 in “Journal of Investigative Dermatology”

Applying a special compound can promote hair growth without harmful side effects.

research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

211 citations , October 2001 in “The FASEB Journal”

Noggin is necessary to start the hair growth phase in skin after birth.

research Treatments for Androgenetic Alopecia and Alopecia Areata

72 citations , January 2001 in “Drugs”

Minoxidil and finasteride treat hair loss; more research needed for other options.

research Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration

194 citations , May 2000 in “Journal of Investigative Dermatology”

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

research Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

231 citations , October 1999 in “Journal of Clinical Investigation”

Activating the Sonic hedgehog gene in mice can start the hair growth phase.

research Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

1 / 1 results

research Hair Growth-Promoting Effect of Recombinant Human Sonic Hedgehog Proteins

3 citations , December 2019 in “Biomedical dermatology”

Sonic hedgehog proteins may help grow hair.