Oncogenic Kras Induces Spatiotemporally Specific Tissue Deformation Through Converting Pulsatile Into Sustained ERK Activation

    September 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Tianchi Xin, Sara Gallini, David G. Gonzalez … Valentina Greco

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, researchers using live mice observed that oncogenic Kras mutation disrupts hair follicle architecture by sustaining ERK signal activation, which affects stem cell behavior and tissue integrity.
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    Research cited in this study 7

    1. Hair Follicle Regeneration Suppresses Ras-Driven Oncogenic Growth Journal of Cell Biology · 2019
    2. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016
    3. Intravital Imaging of Hair Follicle Regeneration in the Mouse Nature Protocols · 2015
    4. Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors Nature Cell Biology · 2013
    5. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    6. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    7. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012

    Related research 2

    1. Reprogramming of Three-Dimensional Microenvironments for In Vitro Hair Follicle Induction bioRxiv (Cold Spring Harbor Laboratory) · 2022
    2. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015