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research miR‐218‐5p regulates skin and hair follicle development through Wnt/β‐catenin signaling pathway by targeting SFRP2

54 citations , April 2019 in “Journal of cellular physiology”

In this study, miR-218-5p was found to enhance hair shaft growth and positively regulate the Wnt signaling pathway by targeting SFRP2 during skin and hair follicle development.

research Tratamiento con Exosomas en Alopecia Areata Difusa Refractaria en Paciente Pediátrico: Reporte de Caso

January 2025 in “Dialnet (Universidad de la Rioja)”

In this case study, a 14-year-old male with treatment-resistant diffuse alopecia areata experienced complete hair regrowth after three monthly sessions of microneedling combined with triamcinolone, dutasteride, and synthetic exosomes, suggesting this therapy might enhance outcomes in refractory cases.

research Tratamiento con Exosomas en Alopecia Areata Difusa Refractaria en Paciente Pediátrico: Reporte de Caso

January 2026 in “Ciencia Latina Revista Científica Multidisciplinar”

In this case study, a 14-year-old boy with treatment-resistant diffuse alopecia areata achieved complete hair regrowth following three monthly sessions of microneedling combined with injections of triamcinolone, dutasteride, and synthetic exosomes, suggesting that exosome-based therapy could be a promising alternative for managing refractory autoimmune alopecia.

research Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, researchers using live mice observed that oncogenic Kras mutation disrupts hair follicle architecture by sustaining ERK signal activation, which affects stem cell behavior and tissue integrity.

research Visualising Androgen Receptor Activity in Male and Female Mice

89 citations , August 2013 in “PloS one”

This study used the "ARE-Luc" mouse model to visualize androgen receptor activity across various tissues in both male and female mice, highlighting the direct action of androgens outside reproductive organs.

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5 / 249 results

community Regrowth with only Nizoral and Lifestyle Changes; focusing on scalp health & nervous system

89 upvotes 8 months ago

The user reported subtle hair regrowth by focusing on scalp health and lifestyle changes, using Nizoral shampoo and methods to reduce inflammation and cortisol, without using finasteride, minoxidil, or other common treatments. Opinions in the conversation varied, with some skeptical of the results and others acknowledging the potential benefits of addressing scalp health and inflammation.

community Could creatine trigger faster hairloss?

29 upvotes 2 years ago

Creatine is reported by many to increase hair loss, though no scientific evidence supports this. Some use finasteride and minoxidil to manage hair loss, while others avoid creatine due to personal experiences.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Hair regrowth without drugs (99% natural) 25M

528 upvotes 4 months ago

A user shared their experience with hair regrowth using supplements like NAC and DIM, and briefly using minoxidil with microneedling. They reported some improvement in hair density, but the community questioned the effectiveness compared to traditional treatments like finasteride.

community DHT is NOT very important for adults, is it?

124 upvotes 5 months ago

A user experienced negative side effects, including low libido and lack of motivation, after using finasteride for hair loss and felt better after stopping it. Others shared similar experiences with finasteride and dutasteride, while some reported no side effects, showing varied individual responses.

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