Hair Follicle Regeneration Suppresses Ras-Driven Oncogenic Growth

    September 2019 in “ Journal of Cell Biology ”
    Cristiana M. Pineda, David Gonzalez, Catherine Matte-Martone … Valentina Greco
    Studysummary This study found that despite carrying an activating Hras mutation, hair follicle stem cells integrate into normal skin without causing tumors, unlike similar mutations in the epidermis, suggesting unique tumor-suppressing mechanisms in hair follicles.
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    Research cited in this study 6

    1. Intravital Imaging of Hair Follicle Regeneration in the Mouse Nature Protocols · 2015
    2. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    3. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    4. Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter Molecular Therapy · 2007
    5. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    6. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005

    Related research 5

    1. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    2. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    3. Epidermal Stem Cells: Practical Perspectives and Potential Uses British Journal of Dermatology · 2009
    4. Epidermal Stem Cells in the Skin Chinese bulletin of Life sciences · 2008
    5. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000