Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter

    October 2007 in “ Molecular Therapy ”
    Masayuki Endo, Philip W. Zoltick, William H. Peranteau … Alan W. Flake
    Studysummary Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.
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    Research cited in this study 3

    1. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    2. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000
    3. The Secret Life of the Hair Follicle Trends in genetics · 1992

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    1. Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter Molecular Therapy · 2007