TLDR Some skin tumors may start from hair follicle stem cells.
The article discussed the origins of basal cell carcinomas (BCCs), presenting evidence that BCCs could arise from hair follicle stem cells, particularly when these cells acquire oncogenic mutations and leave their niche. Using engineered mouse models, the research highlighted the role of Hedgehog (Hh) signaling in BCC development, with varying levels of Hh activation leading to different tumor types. The findings suggested that understanding the cell of origin could improve early cancer detection and treatment.
351 citations,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
1 citations,
January 2016 in “Elsevier eBooks” The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.
232 citations,
January 2013 in “Nature Cell Biology” Understanding where cancer cells come from helps create better prevention and treatment methods.
1 citations,
December 2020 in “International journal of molecular sciences” External factors can cause skin cancer cells that usually don't spread to grow and form tumors in mice.
124 citations,
February 2018 in “Nature Reviews Genetics” Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.
32 citations,
July 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” Transit-amplifying cells are crucial for tissue repair and can contribute to cancer when they malfunction.
