TLDR Some skin tumors may start from hair follicle stem cells.
The article discussed the origins of basal cell carcinomas (BCCs), presenting evidence that BCCs could arise from hair follicle stem cells, particularly when these cells acquire oncogenic mutations and leave their niche. Using engineered mouse models, the research highlighted the role of Hedgehog (Hh) signaling in BCC development, with varying levels of Hh activation leading to different tumor types. The findings suggested that understanding the cell of origin could improve early cancer detection and treatment.
178 citations
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April 2011 in “Journal of Clinical Investigation” Basal cell carcinomas in mice can start from hair follicle stem cells and other skin cell types, depending on signaling levels.
351 citations
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February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
1 citations
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January 2016 in “Elsevier eBooks” The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.
232 citations
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January 2013 in “Nature Cell Biology” Understanding where cancer cells come from helps create better prevention and treatment methods.
54 citations
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April 2020 in “Experimental & Molecular Medicine” Cox-2 significantly contributes to the development and progression of skin and esophageal cancers.
1 citations
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December 2020 in “International journal of molecular sciences” External factors can cause skin cancer cells that usually don't spread to grow and form tumors in mice.
79 citations
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November 2016 in “EMBO Reports” Disruptions in mammary stem cell division can lead to cancer, but targeting these processes might help treat breast cancer.
