Emerging Roles of Transit-Amplifying Cells in Tissue Regeneration and Cancer

The document from July 3, 2017, highlights the complex roles of transit-amplifying cells (TACs) in tissue regeneration and cancer, particularly in the hair follicle and hematopoietic system. TACs, which are intermediate between stem cells and differentiated cells, are essential for tissue generation and homeostasis. In the hair follicle, TACs derived from stem cells proliferate during the anagen phase to produce various cell types for hair growth, but their dysregulation can lead to skin cancers. In the hematopoietic system, multipotent progenitors (MPPs), a type of TAC, sustain long-term hematopoiesis and can transform into acute myeloid leukemia (AML) cells. The document underscores the need to understand TAC biology for advancements in regenerative medicine and the development of treatments for degenerative diseases and cancer.