research Therapy of Acute Myeloid Leukemia
In this study, higher doses of daunorubicin during induction therapy significantly improved complete remission rates in young adults with acute myeloid leukemia.
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5 / 1000+ resultsresearch Androgen receptor signaling as a new target for intervention in acute myeloid leukemia
This study found that targeting androgen receptors with prostate cancer drugs ARN509 and finasteride induced remission and increased survival in a leukemia mouse model, suggesting a potential new treatment approach for acute myeloid leukemia.
research Vitiligo and Alopecia Areata After Donor Lymphocyte Infusions in a Child With Relapsed Acute Myeloid Leukemia
In this case study, donor lymphocyte infusions effectively eradicated measurable residual disease in a patient with relapsed acute myeloid leukemia after hematopoietic cell transplantation, while side effects included the development of vitiligo and alopecia areata, likely due to chronic graft-versus-host disease.
research Challenges associated with the identification of germline variants on myeloid malignancy genomic profiling—a Singaporean experience
This study presented cases where potentially significant germline variants were unexpectedly found during genomic profiling for myeloid malignancies, discussing the challenges in genetic counseling and management, especially when variants don't match the patient's condition.
research Emerging roles of transit‐amplifying cells in tissue regeneration and cancer
This review discusses the emerging roles of transit-amplifying cells in tissue regeneration and cancer formation, highlighting their significance beyond a mere transitional state in hair follicles and the hematopoietic system.
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