Gata6 Promotes Hair Follicle Progenitor Cell Renewal by Genome Maintenance During Proliferation
December 2016
in “
The EMBO Journal
”
Gata6 hair follicle progenitor cells genome maintenance cell proliferation anagen phase DNA damage cell cycle arrest apoptosis Edaradd NF-kB pathway DNA damage repair catagen phase hair growth cessation inducible knockout mice keratinocytes genomic stability hair follicle stem cells hair growth phase cell death hair growth stop skin cells genetic stability
TLDR Gata6 is important for protecting hair growth cells from DNA damage and keeping normal hair growth.
The study from 2016 focused on the transcription factor Gata6 and its role in hair follicle progenitor cell renewal and genome maintenance during cell proliferation. Gata6 was found to be essential for protecting hair follicle progenitor cells from DNA damage during the anagen phase of the hair cycle, thus preventing cell cycle arrest and apoptosis. The study showed that Gata6 stimulates Edaradd levels and NF-kB pathway activation, which are important for DNA damage repair. Loss of Gata6 led to DNA damage, reduced proliferation, and premature transition to the catagen phase, resulting in hair growth cessation. The research involved experiments on mice, including inducible knockout mice, and in vitro assays with cultured keratinocytes. The findings suggest that Gata6 is crucial for maintaining genomic stability in rapidly proliferating cells, which is necessary for normal hair growth and may have implications for understanding Gata6's role in cancer.
