Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice

    December 2020 in “ International journal of molecular sciences ”
    Nadine Brandes, Slavica Hristomanova Mitkovska, Dominik Simon Botermann, W Mäurer, Anna Müllen, Hanna Scheile, Sebastian Zabel, Anke Frommhold, Ina Heß, Heidi Hahn, Anja Uhmann
    TLDR External factors can cause skin cancer cells that usually don't spread to grow and form tumors in mice.
    The study investigated the behavior of Ptch mutant basal cell carcinoma (BCC) precursors in mice and found that their spread was physiologically suppressed, which counteracted tumor formation. This suppression mechanism was crucial in preventing BCC development, suggesting potential therapeutic targets. The research indicated that a homozygous Ptch mutation alone was insufficient for BCC development without external stimuli, highlighting the complexity of BCC pathogenesis. The study used a sample size of 13 mice and emphasized the need for new BCC models and treatment strategies.
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