From Basal Cell Carcinoma Morphogenesis to Alopecia Induced by Hedgehog Inhibitors: Connecting the Dots

    June 2017 in “ British Journal of Dermatology ”
    Clio Dessinioti, Christina Antoniou, Alexander J. Stratigos
    Studysummary This review examines the interaction between hedgehog and Wnt/β-catenin signalling in hair follicles and basal cell carcinoma, linking Hh pathway inhibition to both tumor regression and alopecia.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on academic.oup.com →
    Discuss this study in the Community →

    Research cited in this study 24

    1. Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2017
    2. Managing Adverse Events Associated with Vismodegib in the Treatment of Basal Cell Carcinoma Future oncology · 2016
    3. Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma ˜The œoncologist · 2016
    4. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    5. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    6. Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma Clinical Cancer Research · 2015
    7. Prevention of Alopecia in Medical and Interventional Chemotherapy Patients Journal of Cutaneous Medicine and Surgery · 2015
    8. Hair Loss and Hedgehog Inhibitors: A Class Effect? British Journal of Dermatology · 2014
    9. DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice Journal of Investigative Dermatology · 2014
    10. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    11. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    12. Mommy, Where Do Tumors Come From? The Origins of Basal Cell Carcinomas ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2011
    13. Basal Cell Carcinomas in Mice Arise from Hair Follicle Stem Cells and Multiple Epithelial Progenitor Populations Journal of Clinical Investigation · 2011
    14. The Cycling Hair Follicle as an Ideal Systems Biology Research Model Experimental Dermatology · 2010
    15. Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma Nature Cell Biology · 2010
    16. The New Keratin Nomenclature Journal of Investigative Dermatology · 2006
    17. Hedgehog Signaling in Skin Development and Cancer Experimental Dermatology · 2006
    18. Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression Cancer Research · 2006
    19. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005
    20. Cytokeratins as Markers of Follicular Differentiation American Journal of Dermatopathology · 2001
    21. Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000
    22. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    23. Basal Cell Carcinoma Possibly Originates From the Outer Root Sheath and/or the Bulge Region of the Vellus Hair Follicle Archives of Dermatological Research · 1999
    24. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997

    Related research 1

    1. From Basal Cell Carcinoma Morphogenesis to Alopecia Induced by Hedgehog Inhibitors: Connecting the Dots British Journal of Dermatology · 2017