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GlossaryHedgehog signaling pathway (Hh pathway)

regulates cell growth and development through protein-receptor interactions

The Hedgehog signaling pathway is a crucial mechanism in developmental biology that regulates cell growth, differentiation, and tissue patterning. It involves the Hedgehog proteins binding to receptors on cell surfaces, which then trigger a cascade of intracellular events that influence gene expression. This pathway is essential for proper embryonic development and, when dysregulated, can lead to conditions such as cancer and congenital disorders.

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Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

research Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

1 citations, April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

research Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice

53 citations, May 2010 in “Journal of Cellular Physiology”

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

research Keloid Pathogenesis and Fibroproliferative Properties Are Dependent on Stem Cells Regulated by the Hedgehog-Gli1 Pathway

May 2023 in “Research Square (Research Square)”

Blocking the HEDGEHOG-GLI1 pathway can reduce keloid growth and may be a potential treatment.

research Single Molecule FISH for Hedgehog Signaling in Mouse Skin

December 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hedgehog signaling controls hair follicle development and can affect skin cancer growth.

research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

113 citations, September 2005 in “Journal of Investigative Dermatology”

Applying a special compound can promote hair growth without harmful side effects.

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community Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out

in Progress Pictures 193 upvotes 10 months ago

A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 86 upvotes 7 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)

in Treatment 6 upvotes 6 months ago

The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.

community Finasteride only: Before vs 11 months

in Progress Pictures 437 upvotes 7 months ago

A user shared progress pictures showing hair improvement after 11 months of using finasteride. The user experienced minimal shedding and plans to continue the treatment long-term.

community bye fellas, it’s time to quit this sub

in Progress Pictures 810 upvotes 10 months ago

A user successfully improved their hairline after 15 months using topical minoxidil and dutasteride. Some commenters question the necessity of treatment given the user's original hair condition, while others support early intervention.

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