DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice

    March 2014 in “ Journal of Investigative Dermatology ”
    Anja Uhmann, Ina Heß, Anke Frommhold, Simone König, Sebastian Zabel, Frauke Nitzki, Kai Dittmann, Fred Lühder, Hans Christiansen, Julia Reifenberger, Walter Schulz–Schaeffer, Heidi Hahn
    Image of study
    TLDR Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.
    The document from 2014 presents a study on the development of basal cell carcinoma (BCC) in Ptchflox/flox CD4Cre+/- mice, which have a mutation in the Hedgehog (Hh) signaling pathway component Patched1 (Ptch). The study concluded that the formation of BCC in these mice requires both a genetic predisposition (biallelic loss of Ptch in CD4+ epidermal cells) and an environmental trigger (treatment with the carcinogens DMBA/TPA). The BCCs originated from Ptch-deficient epidermal cells, not from T cells or bone marrow-derived cells, and expressed Gli1, a marker of Hh pathway activation. The study also identified a nonhematopoietic CD4+ cell population in the skin that may be involved in BCC formation. The findings suggest that a second, unknown event, in addition to Ptch loss, is necessary for BCC development, and that the Ras signaling cascade is not implicated in this process.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 17 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

    Similar Research

    5 / 1000+ results