research Targeting Smoothened for Therapeutic Gain
Targeting the Smoothened receptor shows promise for treating certain cancers.
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research Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms
Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.
research Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans
Odontogenic keratocysts are caused by abnormal Hedgehog signaling and can lead to tooth and bone issues.
research Genetic Basis of Skin Appendage Development
Hair, teeth, and mammary glands develop similarly at first but use different genes later.
research The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis
Glypican-1 is important for blood vessel growth in hair follicles and could help treat hair loss.
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5 / 10 resultscommunity Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out
by
majnu_bhai11
in Progress Pictures
193 upvotes
9 months ago A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.
community Topical finasteride now the safest possible path?
by
Least-Debate729
in Finasteride/Dutasteride
84 upvotes
6 months ago Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.
community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)
by
Necessary-Treacle-46
in Treatment
6 upvotes
5 months ago The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.
community Finasteride only: Before vs 11 months
by
Abject_Supermarket14
in Progress Pictures
437 upvotes
6 months ago A user shared progress pictures showing hair improvement after 11 months of using finasteride. The user experienced minimal shedding and plans to continue the treatment long-term.
community Why nobody uses 0.25% (2.5mg/ml)?
by
Jackfruit_Downtown
in Treatment
66 upvotes
1 year ago The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.