Basal Cell Carcinomas Acquire Secondary Mutations to Overcome Dormancy and Progress from Microscopic to Macroscopic Disease

    May 2022 in “ Cell Reports ”
    Kenneth G. Trieu, Shih-Ying Tsai, Markus Eberl … Sunny Y. Wong
    Studysummary In this study, researchers found that basal cell carcinomas with common Hedgehog signaling mutations may require additional mutations to hyperactivate downstream signaling and progress beyond dormancy.
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    Research cited in this study 11

    1. Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice International journal of molecular sciences · 2020
    2. AP-1 and TGFß Cooperativity Drives Non-Canonical Hedgehog Signaling in Resistant Basal Cell Carcinoma Nature Communications · 2020
    3. Hair Follicle Regeneration Suppresses Ras-Driven Oncogenic Growth Journal of Cell Biology · 2019
    4. YAP And TAZ Are Essential For Basal And Squamous Cell Carcinoma Initiation EMBO Reports · 2018
    5. PTCH1 Germline Mutations and the Basaloid Follicular Hamartoma Values in the Tumor Spectrum of Basal Cell Carcinoma Syndrome Anticancer Research · 2018
    6. Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors Nature Cell Biology · 2013
    7. Basal Cell Carcinoma: Molecular Biology and Potential New Therapies Journal of Clinical Investigation · 2012
    8. Basal Cell Carcinomas in Mice Arise from Hair Follicle Stem Cells and Multiple Epithelial Progenitor Populations Journal of Clinical Investigation · 2011
    9. Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma Nature Cell Biology · 2010
    10. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    11. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000