research Nevoid Basal Carcinoma Syndrome (Gorlin Syndrome) and Pronounced Androgenic Alopecia in a Woman with a Novel Mutation p.Leu1159fsx32 in the PTCH Gene
A woman with a new PTCH gene mutation has both Gorlin syndrome and severe hair loss.
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5 / 355 results research Case Report: PTCH1 Splice-Site Mutation and Sonidegib Treatment in Gorlin-Goltz Syndrome: Clinical Insights from a Family Case Study
Personalized sonidegib dosing can effectively treat Gorlin-Goltz syndrome with fewer side effects.
research Sonic Hedgehog Pathway in Wounds in Non-Diabetic Shh-Cre-eGFP/Ptch1-LacZ Mice Treated with MAA Beads
MAA beads improved wound healing in male mice by activating the Shh pathway, but not in females.
research Single Molecule FISH for Hedgehog Signaling in Mouse Skin
Hedgehog signaling controls hair follicle development and can affect skin cancer growth.
research Basal Cell Carcinomas Acquire Secondary Mutations to Overcome Dormancy and Progress from Microscopic to Macroscopic Disease
Basal cell carcinomas need extra mutations to grow from small to large tumors.
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