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New hair regrowth model introduced, imiquimod kills skin cancer cells, T-cadherin loss makes skin cancer more invasive, no strong link between PTCH1 gene and skin cancer after transplant, and male teens more likely to have hereditary hair loss.

Hedgehog signaling controls hair follicle development and can affect skin cancer growth.

A woman with a new PTCH gene mutation has both Gorlin syndrome and severe hair loss.

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

Ptch2 plays a key role in controlling stem cell function and the ability to regenerate after birth.

New hair regrowth model proposed, imiquimod found to kill skin cancer cells, T-cadherin loss linked to invasive skin cancer, no clear gene link to skin cancer after transplant, and study on children's hair loss shows male dominance and genetic ties.

LDE225 is a promising skin-applied treatment for basal cell carcinoma with good skin penetration and effectiveness.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Hedgehog signaling is crucial for mammary gland development over hair follicles.

Laser hair-comb therapy doesn't improve male-pattern hair loss.

Vismodegib is effective for basal cell carcinoma but has severe side effects.

The research suggests new treatments for skin cancer could target specific cell growth pathways.

The document covers various dermatological conditions and their studies.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Understanding where cancer cells come from helps create better prevention and treatment methods.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.