research Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration
TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.
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research DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice
Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.
research Treatment with Light-Emitting Diodes of Wavelength 863 nm Delays DMBA/TPA-Induced Skin Tumor Formation and Decreases Proinflammatory Cytokine Levels in ICR Mice
LED light therapy at 863 nm wavelength can slow down skin tumor growth and reduce inflammation in mice.
research K15 Promoter-Driven Enforced Expression of NKIRAS Exhibits Tumor Suppressive Activity Against the Development of DMBA/TPA-Induced Skin Tumors
The study investigated the role of NKIRAS2 in carcinogenesis using transgenic mice with enforced expression of NKIRAS2 driven by a K15 promoter, primarily active in follicle bulge cells. The results showed that NKIRAS2 expression did not affect epidermal development but effectively suppressed DMBA/TPA-induced skin tumors, indicating a tumor suppressive role in follicle bulges. However, in murine fibroblasts, NKIRAS2 was necessary for HRAS-mutant-driven cellular transformation, with moderate expression enhancing and excessive expression suppressing oncogenic activity. This suggested that NKIRAS2's role in cancer is influenced by cellular context and expression level, exhibiting a biphasic effect on HRAS-driven oncogenesis.
research Induction of Dark Keratinocytes by 12-O-Tetradecanoyl-Phorbol-13-Acetate and Mezerein as an Indicator of Tumor-Promoting Efficiency
TPA is about 50 times more effective at promoting tumors than MZ.
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2 / 2 resultscommunity What factors cause more regrowth for MTF people with hormone replacement therapy?
Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growth phase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.
community Shrooms have done more for my hair loss than all of my hair supplements/medications combined.
Finding acceptance of hair loss through psychedelics, and the potential benefits of shrooms. Discussions include sharing experiences with minoxidil, finasteride, nutrafol, laser therapy, micro needling, as well as mental health concerns such as depression, suicidal thoughts, and self-esteem.