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GlossaryTissue Plasminogen Activator (TPA)

protein that dissolves blood clots by activating plasminogen

Tissue Plasminogen Activator (TPA) is a protein involved in the breakdown of blood clots. It converts plasminogen, an inactive protein in the blood, into plasmin, an enzyme that dissolves clots. TPA is often used in medical treatments to quickly dissolve clots in patients experiencing heart attacks or strokes.

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research Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration

30 citations, February 2017 in “Histochemistry and Cell Biology”

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice

research DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice

11 citations, March 2014 in “Journal of Investigative Dermatology”

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

Treatment with Light-Emitting Diodes of Wavelength 863 nm Delays DMBA/TPA-Induced Skin Tumor Formation and Decreases Proinflammatory Cytokine Levels in ICR Mice

research Treatment with Light-Emitting Diodes of Wavelength 863 nm Delays DMBA/TPA-Induced Skin Tumor Formation and Decreases Proinflammatory Cytokine Levels in ICR Mice

2 citations, February 2022 in “BioMed Research International”

LED light therapy at 863 nm wavelength can slow down skin tumor growth and reduce inflammation in mice.

research Induction of Dark Keratinocytes by 12-O-Tetradecanoyl-Phorbol-13-Acetate and Mezerein as an Indicator of Tumor-Promoting Efficiency

77 citations, January 1980 in “Carcinogenesis”

TPA is about 50 times more effective at promoting tumors than MZ.

research Induction of Ornithine Decarboxylase in Specific Subpopulations of Murine Epidermal Cells Following Multiple Exposures to 12-O-Tetradecanoylphorbol-13-Acetate, Mezerein, and Ethyl Phenylpropriolate

26 citations, January 1992 in “Carcinogenesis”

TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.

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community What factors cause more regrowth for MTF people with hormone replacement therapy?

in Transgender 6 upvotes 1 year ago

Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growth phase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.

community Shrooms have done more for my hair loss than all of my hair supplements/medications combined.

in Satire 408 upvotes 1 year ago

Finding acceptance of hair loss through psychedelics, and the potential benefits of shrooms. Discussions include sharing experiences with minoxidil, finasteride, nutrafol, laser therapy, micro needling, as well as mental health concerns such as depression, suicidal thoughts, and self-esteem.