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GlossaryTissue Plasminogen Activator (TPA)

protein that dissolves blood clots by activating plasminogen

Tissue Plasminogen Activator (TPA) is a protein involved in the breakdown of blood clots. It converts plasminogen, an inactive protein in the blood, into plasmin, an enzyme that dissolves clots. TPA is often used in medical treatments to quickly dissolve clots in patients experiencing heart attacks or strokes.

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DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice

research DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice

11 citations , March 2014 in “Journal of Investigative Dermatology”

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

research Development of an Ex Vivo Human Skin Explant Model to Examine Candidate Gene Functions in the Hair Follicle and Epidermis

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

The model can effectively test gene functions and drug responses in human skin.

research Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration

30 citations , February 2017 in “Histochemistry and Cell Biology”

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

research Tumor Cell Adhesion as a Risk Factor for SLN Metastasis and Predictor of Disease Recurrence in Primary Cutaneous Melanoma

April 2016 in “Journal of Investigative Dermatology”

Tumor cell adhesion is linked to higher risk of SLN metastasis and melanoma recurrence, and a model including these factors predicts these outcomes better than one with just clinical data.

research Suppression of Vitamin D Receptor and Induction of Retinoid X Receptor Alpha Expression During Squamous Differentiation of Cultured Keratinocytes

15 citations , March 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.

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community What factors cause more regrowth for MTF people with hormone replacement therapy?

in Transgender 6 upvotes 2 years ago

Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growth phase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.

community Shrooms have done more for my hair loss than all of my hair supplements/medications combined.

in Satire 408 upvotes 2 years ago

Finding acceptance of hair loss through psychedelics, and the potential benefits of shrooms. Discussions include sharing experiences with minoxidil, finasteride, nutrafol, laser therapy, micro needling, as well as mental health concerns such as depression, suicidal thoughts, and self-esteem.