Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma

The document reviewed the adverse events associated with Hedgehog pathway inhibitors (HPIs) in patients with advanced basal cell carcinoma (BCC), focusing on common side effects like muscle spasms, dysgeusia, alopecia, weight loss, and fatigue. These side effects, often mild to moderate but persistent, necessitated effective management strategies such as dose adjustments, supportive care, and patient education to improve adherence and quality of life. The study emphasized the importance of managing these adverse events to ensure patients could continue benefiting from HPI therapy, with specific strategies for each type of side effect, including dietary adjustments, nutritional support, and physical and psychosocial interventions.