Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology
June 2019
in “
International journal of dermatology and venereology
”
Hedgehog Signaling Pathway Sonic hedgehog Shh hair follicle development basal cell carcinoma BCC cutaneous squamous cell carcinoma CSCC melanoma sebaceous carcinoma SC T-cell lymphoma B-cell lymphoma Ptch Smo Gli1 VEGF Gli2 NPM-ALK fusion diffuse large B-cell lymphoma DLBCL HSP inhibitors vismodegib sonidegib HSP
TLDR The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.
The Hedgehog Signaling Pathway (HSP) played a significant role in skin formation, hair development, and various skin cancers. The absence of Sonic hedgehog (Shh) hindered normal hair follicle development. Aberrant HSP activation was linked to cancers like basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (CSCC), melanoma, sebaceous carcinoma (SC), and T-cell and B-cell lymphomas. In BCC, mutations in HSP components such as Ptch and Smo were common. CSCC growth was influenced by Gli1 and VEGF, while melanoma involved Gli1 and Gli2 in tumor invasion. SC showed high levels of Gli2 and Smo, and T-cell lymphomas had elevated Shh and Gli1 due to NPM-ALK fusion. B-cell lymphomas, particularly diffuse large B-cell lymphoma (DLBCL), exhibited high Shh and related proteins, with HSP activation linked to drug resistance. HSP inhibitors like vismodegib and sonidegib were approved for advanced BCCs, and other inhibitors were under investigation, highlighting HSP's potential as a therapeutic target.
