ILK Modulates Epithelial Polarity and Matrix Formation in Hair Follicles

    December 2013 in “ Molecular biology of the cell ”
    Alena Rudkouskaya, Ian Welch, Lina Dagnino
    Studysummary This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.
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    Research cited in this study 13

    1. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    2. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    3. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation, and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012
    4. Emerging Role of ILK and ELMO2 in the Integration of Adhesion and Migration Pathways Cell Adhesion & Migration · 2012
    5. Targeted Inactivation of Integrin-Linked Kinase in Hair Follicle Stem Cells Reveals an Important Modulatory Role in Skin Repair After Injury Molecular Biology of the Cell · 2011
    6. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    7. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    8. Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008
    9. Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling Development · 2008
    10. Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis Genes & Development · 2008
    11. Scratching the Surface of Skin Development Nature · 2007
    12. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    13. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002

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    4. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    5. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981