Targeted Inactivation of Integrin-Linked Kinase in Hair Follicle Stem Cells Reveals an Important Modulatory Role in Skin Repair After Injury

    May 2011 in “ Molecular Biology of the Cell ”
    Kerry‐Ann Nakrieko, Alena Rudkouskaya, Timothy S. Irvine … Lina Dagnino
    Studysummary In this study, gene inactivation in mouse hair follicle stem cells lacking ILK impaired wound healing by reducing their progeny’s contribution to the regenerating epidermis, but did not affect hair follicle regeneration.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on molbiolcell.org →
    Discuss this study in the Community →

    Research cited in this study 7

    1. Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation Cancer research · 2009
    2. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    3. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    4. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    5. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    6. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    7. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003

    Related research 6

    1. Promoting Effect of Hair Follicle Stem Cells in the Wound Healing of Skin Chin J Cell Stem Cell (Electronic Edition) · 2017
    2. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    3. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    4. Keratins of the Human Hair Follicle International review of cytology · 2005
    5. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    6. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003