Heparan Sulfate Regulates Hair Follicle and Sebaceous Gland Morphogenesis and Homeostasis

    July 2014 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Vivien Jane Coulson‐Thomas, Tarsis F. Gesteira, Jeffrey D. Esko, Winston W.‐Y. Kao
    Studysummary This study suggests that heparan sulfate is crucial for regulating hair follicle formation, cycling, and gland morphogenesis, with its ablation leading to continuous hair growth and increased gland activity in mice.
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    Research cited in this study 15

    1. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    2. Recent Advances in the Epidermal Growth Factor Receptor/Ligand System Biology on Skin Homeostasis and Keratinocyte Stem Cell Regulation Journal of Dermatological Science · 2013
    3. Wnt10b Promotes Differentiation of Mouse Hair Follicle Melanocytes International Journal of Medical Sciences · 2013
    4. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    5. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    6. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    7. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    8. Cutaneous Consequences of Inhibiting EGF Receptor Signaling In Vivo: Normal Hair Follicle Development, But Retarded Hair Cycle Induction and Inhibition of Adipocyte Growth in EgfrWa5 Mice Journal of Dermatological Science · 2010
    9. Heparanase 1: A Key Participant of Inner Root Sheath Differentiation Program and Hair Follicle Homeostasis Experimental Dermatology · 2008
    10. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    11. Abnormalities in the Hair Morphology of Patients with Some but Not All Types of Mucopolysaccharidoses European journal of pediatrics · 2007
    12. Genetic Basis of Skin Appendage Development Seminars in cell & developmental biology · 2007
    13. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    14. Expression of the Intermediate Filament Keratin Gene K15 in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998
    15. Correlation of Proteolytic Activities of Organ Cultured Intact Mouse Skin With Defined Hair Cycle Stages Journal of Dermatological Science · 1994

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    1. Overexpression Of Sonic Hedgehog Suppresses Embryonic Hair Follicle Morphogenesis Developmental Biology · 2003