TLDR Heparanase is essential for hair follicle health and inner root sheath differentiation.
The study investigated the role of heparanase, a heparan sulphate endo-glycosidase, in human hair biology, particularly its expression in hair follicles. It was found that heparanase was primarily located in the inner root sheath (IRS) of human hair follicles and was restricted to the anagen phase. Inhibition of heparanase in in vitro cultured hair follicles led to a catagen-like process, characterized by hair shaft retreat, decreased Ki67-positive cells, formation of an epithelial strand, and loss of IRS markers. These findings suggested that heparanase played a crucial role in IRS differentiation and hair follicle homeostasis.
28 citations
,
August 2005 in “Journal of Investigative Dermatology” TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.
77 citations
,
April 2005 in “Journal of Investigative Dermatology” Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.
29 citations
,
April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
854 citations
,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
34 citations
,
September 1997 in “Acta Dermato Venereologica” 47 citations
,
July 1997 in “British Journal of Dermatology” The inner root sheath is crucial for hair follicle stability during the transition from growth to involution.
36 citations
,
September 1996 in “PubMed” 133 citations
,
July 1994 in “Journal of Dermatological Science” 
94 citations
,
February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
745 citations
,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
103 citations
,
December 1986 in “Journal of Investigative Dermatology”
5 citations
,
January 2009 in “Dermato-endocrinology” ADAM 10 and ADAM 12 proteins are involved in different stages of hair growth and could be targets for treating hair disorders.
22 citations
,
June 2008 in “Experimental Dermatology” Heparanase is essential for hair follicle health and inner root sheath differentiation.
45 citations
,
April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
10 citations
,
October 2000 in “PubMed” E6/E7 oncogenes in hair follicles cause continuous hair growth by skipping the resting phase.
79 citations
,
December 1999 in “Mechanisms of Development” Whn is crucial for hair growth in certain areas by controlling a specific gene.
