Wnt10b Promotes Differentiation of Mouse Hair Follicle Melanocytes

    January 2013 in “ International Journal of Medical Sciences ”
    Jixing Ye, Tian Yang, Haiying Guo, Yinhong Tang, Fang Deng, Yuhong Li, Yizhan Xing, Li Yang, Ke Yang
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    TLDR Wnt10b helps hair follicle cells mature and produce pigment.
    The study investigated the role of Wnt10b in hair follicle melanocytes using Dct-LacZ transgenic mice and found that Wnt10b was primarily expressed near and within melanocytes during the anagen stage of the hair cycle. It was shown that Wnt10b promoted melanocyte maturation and pigmentation in the hair bulbs. Additionally, by overexpressing Wnt10b in iMC23 cells, the study demonstrated that Wnt10b facilitated melanocyte differentiation through the activation of canonical Wnt signaling.
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