Plasticity of Differentiated Cells in Wound Repair and Tumorigenesis, Part II: Skin and Intestine

    August 2018 in “ Disease Models & Mechanisms ”
    Joseph Burclaff, Jason C. Mills
    TLDR Mature cells can re-enter the cell cycle and potentially lead to cancer.
    The document reviewed the concept of regenerative cellular plasticity, focusing on the skin and intestine, and explored how mature cells might contribute to tumorigenesis through a process called paligenosis. This process allows differentiated cells to re-enter the cell cycle, potentially accumulating oncogenic mutations in a model termed the 'cyclical hit' model of tumorigenesis. While differentiation and repair are well-studied in the skin and intestine, the exact role of mature cells in tumorigenesis was less clear. The review aimed to identify conserved mechanisms across the skin, intestine, stomach, and pancreas that could inform cancer therapy development.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 224 results

      community Comprehensive Microneedling Guide

      in Microneedling  293 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Dr. Bloxham's Verteporfin Trial

      in Research/Science  30 upvotes 1 year ago
      Dr. Bloxham's trial is testing verteporfin on hair transplant patients to see if it can improve hair regrowth in treated areas. People are discussing the potential for follicle regeneration, expected results timeline, and concerns about side effects like cancer.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Similar Research

    5 / 1000+ results