Obesity and Wound Healing: Focus on Mesenchymal Stem Cells

    March 2023 in “ Life ”
    Antonio Alma, Guya Diletta Marconi, Elena Rossi, Cristina Magnoni, Alessia Paganelli
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    TLDR Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.
    The review "Obesity and Wound Healing: Focus on Mesenchymal Stem Cells" discusses the negative impact of obesity on wound healing, with a specific focus on adipose-derived stem cells (ADSCs). Obesity, which affects 1.7 billion people globally, often leads to chronic ulcers and impairs wound healing due to associated conditions like cardiovascular disorders and diabetes. ADSCs, found in adipose tissue, have regenerative and immunological functions that regulate skin regeneration. However, obesity can alter the cellular plasticity and regenerative functions of ADSCs. The review also notes that obesity can lead to MSC impairment, resulting in increased production of inflammatory cytokines, cell senescence, and reduced cell proliferation, which could contribute to impaired wound healing and chronic wounds in obese individuals. Despite these challenges, MSC-based therapies are being explored for obesity-related disorders, but their clinical efficacy remains to be determined.
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