Research Advances of Tissue-Derived Extracellular Vesicles in Cancers

This review highlights the importance of tissue-derived extracellular vesicles (EVs) in cancer research, emphasizing their role in reflecting the tissue microenvironment and facilitating cell communication. It discusses advanced technologies for isolating and purifying tissue EVs, and their significance in understanding tumor mechanisms. The review also explores the potential of tissue EVs in clinical applications, such as early diagnosis, prognosis, and treatment of cancers, while evaluating the strengths and weaknesses of various isolation methods and the importance of protein characterization for purity. The need for tailored protocols based on tissue characteristics and consideration of potential risks in therapeutic use is also emphasized.