Extracellular Vesicles for Regenerative Medicine Applications

    July 2022 in “ Applied Sciences ”
    Raphael J. Crum, Héctor Capella‐Monsonís, Stephen F. Badylak, George S. Hussey
    TLDR Extracellular vesicles can help repair and regenerate tissues with less risk of rejection.
    The document reviewed the potential of extracellular vesicles (EVs) in regenerative medicine, emphasizing their role in tissue repair and regeneration. EVs, including exosomes and microvesicles, were highlighted for their ability to transfer functional cargo between cells, influencing cellular behavior and promoting healing. The review noted the promise of EV-based therapies in pre-clinical studies for various conditions, such as cardiac, skin, and bone regeneration, and their potential as alternatives to traditional cell-based therapies. Despite the promise, challenges such as large-scale production, characterization, and safety concerns remained. The document also mentioned the growing interest in EV technology within the pharmaceutical industry, with numerous companies and clinical trials exploring their therapeutic applications. Further research was needed to optimize EV processes and address these challenges for clinical translation.
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