Extracellular Vesicles in Skin Wound Healing

    August 2021 in “ Pharmaceuticals ”
    Deimantė Narauskaitė, Gabrielė Vydmantaitė, Justina Rusteikaitė, Revathi Sampath, Akvilė Rudaitytė, Gabija Stašytė, María Isabel Aparicio Calvente, Aistė Jekabsone
    TLDR Extracellular vesicles help heal skin wounds and could be used for better treatments.
    The review discussed the potential of extracellular vesicles (EVs) in enhancing skin wound healing across all four phases: hemostasis, inflammation, proliferation, and remodeling. EVs from sources like mesenchymal stem cells (MSCs) and plants were shown to promote cell proliferation, migration, and angiogenesis. MSC-derived EVs, particularly from umbilical cord, adipose tissue, and bone marrow, were effective in diabetic wound healing, influencing processes like coagulation and collagen synthesis through pathways such as PI3K/Akt and Wnt/β-catenin. Plant-derived EVs, though less studied, showed promise as cost-effective drug delivery systems with anti-oxidative and anti-inflammatory effects. The review highlighted the need for further research to fully understand EV mechanisms and suggested future development of smart hydrogels and multifunctional biomaterials to optimize EV delivery and wound healing outcomes.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 36 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Has anyone tried Exosomes from Musely or somewhere else?

      in Hair Systems  9 upvotes 11 months ago
      Exosomes from Musely are being discussed as a topical hair loss treatment containing ingredients like latanoprost, caffeine, cetirizine, melatonin, vitamin D3, vitamin E, and biotin. Users are curious about its effectiveness and potential side effects, noting it may take 4-6 months to see results.

      community Serum based on plant extracts boosts hair growth in weeks.

      in Treatment  46 upvotes 5 months ago
      A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

    Similar Research

    5 / 1000+ results