Hopes and Limits of Adipose-Derived Stem Cells and Mesenchymal Stem Cells in Wound Healing
February 2020
in “
International journal of molecular sciences
”
adipose-derived stem cells ADSCs mesenchymal stem cells MSCs skin regeneration wound healing autocrine pathways paracrine pathways dermal fibroblasts endothelial cells keratinocytes extracellular matrix ECM macrophage inflammatory phenotypes angiogenesis granulation tissue formation skin aging stem cells skin cells cell regeneration skin structure inflammation blood vessel formation tissue formation
TLDR ADSCs help in wound healing and skin regeneration but need more research for full understanding.
The document reviewed the potential and limitations of adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) in wound healing. It highlighted that both ADSCs and MSCs showed promise in promoting wound repair through mechanisms like immunomodulation, differentiation, and secretion of bioactive molecules. However, their effectiveness could be influenced by factors such as donor age, cell isolation methods, and the specific wound environment. Despite encouraging experimental results, translating these findings into clinical practice faced challenges, including ensuring consistent cell quality and understanding long-term effects. Further research was needed to fully understand the mechanisms and optimize the therapeutic use of ADSCs and MSCs in clinical settings.
