Skin Cell-Derived Extracellular Vesicles: A Promising Therapeutic Strategy for Cutaneous Injury

January 2022 in “ Burns and trauma ”

Min Wang, Peipei Wu, Junjie Huang, Wenhui Liu, Hui Qian, Yaoxiang Sun, Hui Shi

extracellular vesicles epidermal cells fibroblasts vascular endothelial cells inflammatory cells wound healing paracrine mechanisms endocrine mechanisms tissue repair bioactive substances tissue regeneration granulation tissue hyperplasia scar formation regenerative medicine wound therapy

TLDR Skin cell-derived vesicles can help heal skin injuries effectively.

Extracellular vesicles (EVs) derived from skin cells, such as epidermal cells, fibroblasts, vascular endothelial cells, and inflammatory cells, play a crucial role in wound healing through paracrine and endocrine mechanisms. These EVs facilitate tissue repair by carrying bioactive substances that aid in the healing process. The study highlights the potential of using skin cell-derived EVs as a promising therapeutic strategy for cutaneous injuries, emphasizing their role in tissue regeneration, granulation tissue hyperplasia, and scar formation. This approach offers new insights into regenerative medicine and wound therapy.

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