Skin Cell-Derived Extracellular Vesicles: A Promising Therapeutic Strategy for Cutaneous Injury

January 2022 in “ Burns and trauma ”

Min Wang, Peipei Wu, Junjie Huang, Wenhui Liu, Hui Qian, Yaoxiang Sun, Hui Shi

extracellular vesicles epidermal cells fibroblasts vascular endothelial cells inflammatory cells wound healing paracrine mechanisms endocrine mechanisms tissue repair bioactive substances tissue regeneration granulation tissue hyperplasia scar formation regenerative medicine wound therapy

Studysummary This review discusses the role of extracellular vesicles from specific skin cells in wound healing, emphasizing their potential in regenerative medicine and reporting no new experimental results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Extracellular vesicles (EVs) derived from skin cells, such as epidermal cells, fibroblasts, vascular endothelial cells, and inflammatory cells, play a crucial role in wound healing through paracrine and endocrine mechanisms. These EVs facilitate tissue repair by carrying bioactive substances that aid in the healing process. The study highlights the potential of using skin cell-derived EVs as a promising therapeutic strategy for cutaneous injuries, emphasizing their role in tissue regeneration, granulation tissue hyperplasia, and scar formation. This approach offers new insights into regenerative medicine and wound therapy.

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Research cited in this study

18 / 18 results

research Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

12 citations , January 2022 in “Cells”

This study found that early passage dermal papilla cell-derived extracellular vesicles, combined with specialized medium, helped adipose-derived stem cells develop dermal papilla-like properties.

research Engineered Extracellular Vesicle Mimetics from Macrophage Promotes Hair Growth in Mice and Human Hair Follicle Growth

8 citations , October 2021 in “Experimental cell research”

This study found that macrophage-engineered extracellular vesicle mimetics may promote hair regrowth, presenting a potential alternative to extracellular vesicles for overcoming clinical production challenges.

research Platelet Therapeutics to Improve Tissue Regeneration and Wound Healing: Physiological Background and Methods of Preparation

14 citations , July 2021 in “Biomedicines”

This review discusses the roles of platelets in hemostasis and wound repair, the preparation methods for platelet concentrates, and their therapeutic applications in medicine and dentistry, reporting no new clinical results.

research Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration

74 citations , June 2021 in “Frontiers in Cell and Developmental Biology”

This study suggests that exosomal miRNAs from human amniotic fluid stem cells may inhibit myofibroblast differentiation and reduce fibrotic scarring in wound healing.

research Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion

9 citations , June 2021 in “Nutrients”

In this study, fisetin applied to the dorsal skin of mice activated hair follicle stem cells through exosome secretion from keratinocytes, promoting hair growth.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

This study found that extracellular vesicles from low-passage dermal papilla cells may activate hair growth by delivering miR-140-5p, which downregulates BMP2 signaling, suggesting potential therapeutic targets for alopecia.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.

research Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

139 citations , May 2020 in “Stem Cell Research & Therapy”

In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.

research Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth

46 citations , January 2020 in “Theranostics”

This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.

research Epidermal Stem Cells in Wound Healing and Their Clinical Applications

129 citations , July 2019 in “Stem Cell Research & Therapy”

This review examines the role of epidermal stem cells in wound healing, discussing their characteristics and mechanisms, but does not report new clinical results.

research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

37 citations , June 2019 in “Stem cells”

This study found that extracellular vesicles from stimulated human dermal fibroblasts enhanced hair follicle growth ex vivo by activating dermal papilla cells and involving the Norrin and β-catenin pathways.

Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , March 2019 in “Experimental Dermatology”

This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.

research Wound Healing: A Cellular Perspective

1160 citations , November 2018 in “Physiological Reviews”

This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.