Skin Cell-Derived Extracellular Vesicles: A Promising Therapeutic Strategy for Cutaneous Injury

January 2022 in “ Burns and trauma ”

Min Wang, Peipei Wu, Junjie Huang, Wenhui Liu, Hui Qian, Yaoxiang Sun, Hui Shi

extracellular vesicles epidermal cells fibroblasts vascular endothelial cells inflammatory cells wound healing paracrine mechanisms endocrine mechanisms tissue repair bioactive substances tissue regeneration granulation tissue hyperplasia scar formation regenerative medicine wound therapy

TLDR Skin cell-derived vesicles can help heal skin injuries effectively.

Extracellular vesicles (EVs) derived from skin cells, such as epidermal cells, fibroblasts, vascular endothelial cells, and inflammatory cells, play a crucial role in wound healing through paracrine and endocrine mechanisms. These EVs facilitate tissue repair by carrying bioactive substances that aid in the healing process. The study highlights the potential of using skin cell-derived EVs as a promising therapeutic strategy for cutaneous injuries, emphasizing their role in tissue regeneration, granulation tissue hyperplasia, and scar formation. This approach offers new insights into regenerative medicine and wound therapy.

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Skin Cell-Derived Extracellular Vesicles: A Promising Therapeutic Strategy for Cutaneous Injury

Research cited in this study

research Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

research Engineered Extracellular Vesicle Mimetics from Macrophage Promotes Hair Growth in Mice and Human Hair Follicle Growth

research Platelet Therapeutics to Improve Tissue Regeneration and Wound Healing: Physiological Background and Methods of Preparation

research Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion

research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research The Immune Functions of Keratinocytes in Skin Wound Healing

research Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth

research Epidermal Stem Cells in Wound Healing and Their Clinical Applications

research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

research Wound Healing: A Cellular Perspective

research Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

research Advances in Skin Grafting and Treatment of Cutaneous Wounds

research Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles

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