Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration
June 2021
in “
Frontiers in Cell and Developmental Biology
”
human amniotic fluid stem cell-derived exosomes hAFSC-exo cutaneous regeneration hair follicles miRNAs let-7-5p miR-21-5p TGF-β signaling pathway myofibroblast extracellular matrix stem cell exosomes skin regeneration hair follicle regeneration microRNAs transforming growth factor beta fibrotic scarring
TLDR Human amniotic fluid stem cell-derived exosomes improve wound healing and reduce scarring.
The study investigated the effects of human amniotic fluid stem cell-derived exosomes (hAFSC-exo) on wound healing and cutaneous regeneration in a rat model. It was found that hAFSC-exo accelerated wound healing, improved hair follicle regeneration, and reduced fibrotic scarring by inhibiting myofibroblast formation through the down-regulation of the TGF-β signaling pathway. The exosomes promoted nerve and vessel reconstruction and enhanced cutaneous cell proliferation, resembling scarless fetal wound healing. The study involved 5 rats per group for in vivo experiments and 3 replicates for in vitro analyses, suggesting that hAFSC-exo could be a promising cell-free therapy for enhancing skin repair and reducing scarring, with potential applications in hair follicle regeneration and anti-scarring treatments.
