Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia

    March 2025 in “ World Journal of Stem Cells
    Yu Fu, Yao-ting Han, Junling Xie, Rong-qi Liu, Bo Zhao, Xing-Liao Zhang, Jun Zhang, Jing Zhang
    TLDR Stem cell exosomes may help treat hair loss by promoting hair growth.
    This study examines the potential of human adipose-derived mesenchymal stem cell exosomes (hADSC-Exos) in treating androgenetic alopecia (AGA) by enhancing hair follicle development. The research highlights that hADSC-Exos promote dermal papillary cell proliferation and migration through the Wnt/β-catenin signaling pathway, counteracting the effects of dihydrotestosterone. In a mouse model with 6 mice per group, hADSC-Exos treatment showed promising results in hair growth compared to controls. The study suggests that hADSC-Exos could be a promising, cell-free therapeutic approach for AGA, with advantages such as regenerative potential and minimal invasiveness, and recommends further exploration of administration methods and long-term safety.
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