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    Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia

    March 2025 in “ World Journal of Stem Cells ”
    Yu Fu, Yao-ting Han, Junling Xie … Jing Zhang
    Studysummary This study found that human adipose-derived MSC exosomes (hADSC-Exos) may enhance dermal papillary cell proliferation and migration by activating the Wnt/β-catenin signaling pathway, potentially reversing the effects of dihydrotestosterone in androgenetic alopecia.
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    Research cited in this study 31

    1. Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field Stem Cell Research & Therapy · 2024
    2. LncRNA RP11-818O24.3 Promotes Hair Follicle Recovery via FGF2-PI3K/Akt Signal Pathway Cytotechnology · 2024
    3. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    4. Cell-Free Fat Extract Restores Hair Loss: A Novel Therapeutic Strategy for Androgenetic Alopecia Stem Cell Research & Therapy · 2023
    5. Androgenetic Alopecia: Therapy Update Drugs · 2023
    6. Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 International Journal of Molecular Sciences · 2023
    7. The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia International Journal of Biological Sciences · 2023
    8. Autologous Platelet-Rich Plasma Treatment for Androgenic Alopecia: A Systematic Review and Meta-Analysis of Clinical Trials on Patient Safety, Efficacy and Outcomes Plastic and Reconstructive Surgery · 2022
    9. Stimulation of Hair Growth by Tianma Gouteng Decoction: Mechanisms Based on Chemical Analysis, Systems Biology, and Experimental Evaluation Frontiers in Pharmacology · 2022
    10. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    11. A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy Advanced healthcare materials/Advanced Healthcare Materials · 2022
    12. The First Broad Replication Study of SNPs and a Pilot Genome-Wide Association Study for Androgenetic Alopecia in Asian Populations Journal of Cosmetic Dermatology · 2022
    13. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    14. Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia Journal of immunology research · 2022
    15. Nanostructured Drug Delivery Systems for Targeting 5-Alpha-Reductase Inhibitors to the Hair Follicle Pharmaceutics · 2022
    16. Exosomes Derived From Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation Through The Wnt3a/Beta-Catenin Signaling Pathway Oxidative Medicine and Cellular Longevity · 2022
    17. Systematic Review: The Platelet-Rich Plasma Use in Female Androgenetic Alopecia as Effective Autologous Treatment of Regenerative Plastic Surgery Journal of Plastic Reconstructive and Aesthetic Surgery · 2021
    18. Androgenetic Alopecia in Transgender and Gender Diverse Populations: A Review of Therapeutics Journal of The American Academy of Dermatology · 2021
    19. The Effectiveness of Low-Level Light/Laser Therapy on Hair Loss Facial plastic surgery & aesthetic medicine · 2021
    20. Safety and Efficacy of ALRV5XR in Women with Androgenetic Alopecia or Telogen Effluvium: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial EClinicalMedicine · 2021
    21. In Vitro and Clinical Evaluation of Umbilical Cord-Derived Mesenchymal Stromal Cell-Conditioned Media for Hair Regeneration Journal of Cosmetic Dermatology · 2021
    22. Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy Journal of the European Academy of Dermatology and Venereology · 2020
    23. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    24. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    25. Post-Finasteride Syndrome: An Emerging Clinical Problem Neurobiology of Stress · 2019
    26. Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia International Journal of Molecular Sciences · 2019
    27. Overexpression of Nanog in Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Dermal Papilla Cell Activity and Promotes Hair Follicle Regeneration Experimental and Molecular Medicine · 2019
    28. Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia Journal of Visualized Experiments · 2018
    29. Preparation and In Vivo Evaluation of Lecithin-Based Microparticles for Topical Delivery of Minoxidil Archives of Pharmacal Research · 2017
    30. Hair Growth Promoting Effect of White Wax and Policosanol from White Wax on the Mouse Model of Testosterone-Induced Hair Loss Biomedicine & Pharmacotherapy · 2017
    31. Potential Synergistic Effects of Human Placental Extract and Minoxidil on Hair Growth-Promoting Activity in C57BL/6J Mice Clinical and Experimental Dermatology · 2015