Stimulation of Hair Growth by Tianma Gouteng Decoction: Mechanisms Based on Chemical Analysis, Systems Biology, and Experimental Evaluation

December 2022 in “ Frontiers in Pharmacology ”

Yanyan Zhang, Shiqian Zhang, Yunluan Long, Wuji Wang, Fanpan Du, Jingjie Li, Jiashi Feng, Zheng Li

Tianma Gouteng decoction quercetin luteolin fisetin wogonin oroxylin A boldine tetrahydroalstonine galangin GSK3β Wnt/β-catenin signaling pathway hair follicle development hair follicle regeneration alopecia hair growth TGD hair loss hair follicles

TLDR Tianma Gouteng decoction may help prevent hair loss and promote hair growth.

The study investigates the effects of Tianma Gouteng decoction (TGD), a traditional Chinese medicine, on hair growth and alopecia. Using chemical analysis, systems biology, and experimental evaluation, the research identified 39 bioactive components in TGD, including quercetin, luteolin, fisetin, wogonin, oroxylin A, boldine, tetrahydroalstonine, and galangin, that could potentially treat hair loss. The study also identified GSK3β as a potential target for TGD treatment of alopecia, as it plays a key role in the Wnt/β-catenin signaling pathway, crucial for hair follicle development and regeneration. Experimental results from a murine model confirmed the efficacy of TGD in promoting hair growth. The study concluded that TGD has positive therapeutic anti-alopecia effects, making it a potential natural medicine for preventing hair loss.

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