5-Bromo-3,4-Dihydroxybenzaldehyde Promotes Hair Growth Through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

March 2022 in “ Molecules ”

Jingoo Kang, Youn Kyung Choi, Sang-Chul Han, Hyunwoo Nam, Gilwoo Lee, Jihoon Kang, Young Sang Koh, Jin‐Won Hyun, Eun-Sook Yoo, Hee‐Kyoung Kang

5-bromo-3,4-dihydroxybenzaldehyde BDB Wnt/β-catenin pathway autophagy pathway TGF-β pathway dermal papilla cells DPCs hair follicles Smad2 apoptosis epithelial cells Wnt pathway

TLDR 5-Bromo-3,4-dihydroxybenzaldehyde could potentially help hair growth by activating certain cell pathways and inhibiting others.

The study investigated the effects of 5-bromo-3,4-dihydroxybenzaldehyde (BDB) on hair growth using rat vibrissa follicles and dermal papilla cells (DPCs). BDB was found to increase the length of hair fibers and the proliferation of DPCs, which regulate hair growth. It also activated the Wnt/β-catenin and autophagy pathways, known to promote hair growth, and inhibited the TGF-β pathway, known to inhibit hair growth. BDB also inhibited TGF-β1-induced activation of Smad2 in DPCs, which is known to induce apoptosis of epithelial cells in hair follicles. These findings suggest that BDB could potentially be used as a treatment for hair loss.

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4 / 4 results

research 5-Bromo-3,4-Dihydroxybenzaldehyde Promotes Hair Growth Through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

7 citations , March 2022 in “Molecules”

5-Bromo-3,4-dihydroxybenzaldehyde could potentially help hair growth by activating certain cell pathways and inhibiting others.

5-Bromo-3,4-Dihydroxybenzaldehyde Promotes Hair Growth Through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

Cited in this study

research Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/β-Catenin Pathway in Dermal Papilla Cells

research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

research Clinical Trials and Hair Loss

research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

research Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2

research An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia

research Undariopsis Peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways

research Promotion Effect of Apo-9'-Fucoxanthinone from Sargassum Muticum on Hair Growth via the Activation of Wnt/β-Catenin and VEGF-R2

research Pathobiology of Chemotherapy-Induced Hair Loss

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

research Alopecia Areata Update

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

research Minoxidil: Mechanisms of Action on Hair Growth

research Common Hair Loss Disorders

research Androgens and Alopecia

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Molecular Mechanisms of Androgenetic Alopecia

research Efficacy and Tolerability of Hairgain in Individuals with Hair Loss: A Placebo-Controlled, Double-Blind Study

research Cyclical Changes in Rat Vibrissa Follicles Maintained In Vitro

research Treatment of Hair Loss

research The Biology of Hair Follicles

research Finasteride in the Treatment of Men with Androgenetic Alopecia

research Hypertrichosis due to minoxidil

research Hypertrichosis due to minoxidil

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