Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/β-Catenin Pathway in Dermal Papilla Cells

May 2020 in “ Biomolecules & Therapeutics ”

Jingoo Kang, Youn Kyung Choi, Young‐Sang Koh, Jin‐Won Hyun, Jihoon Kang, Kwang-Sik Lee, Chun Mong Lee, Eun-Sook Yoo, Hee‐Kyoung Kang

vanillic acid anagen phase PI3K/Akt/β-Catenin pathway dermal papilla cells cyclin D1 CDK6 Cdc2 p34 cell proliferation dihydrotestosterone DHT androgenetic alopecia hair growth phase DPCs cell cycle proteins hair loss alopecia

Studysummary This study found that vanillic acid from wheat bran promoted dermal papilla cell proliferation, potentially stimulating hair growth by activating the PI3K/Akt and Wnt/β-catenin pathways.

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