Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells

December 2022 in “ Nutrients ”

Jingoo Kang, Youn Kyung Choi, Sang-Chul Han, Hyeon Gyu Kim, Seok Won Hong, Jung-Eun Kim, Jae-Hoon Kim, Jin‐Won Hyun, Eun-Sook Yoo, Hee‐Kyoung Kang

limonin anagen signaling dermal papilla cells cyclin D1 p27 BrdU-positive cells autophagy Wnt/β-catenin pathway PI3K/AKT pathway hair-cycle changes hair growth hair loss treatment

TLDR Limonin from young citrus fruits may help with hair growth by affecting cell growth and hair cycle pathways.

The study found that limonin, a compound in immature citrus fruits, promotes hair growth by increasing the proliferation of rat dermal papilla cells (rDPC). This is achieved by altering levels of proteins cyclin D1 and p27, increasing BrdU-positive cells, and activating autophagy. Limonin also activated the Wnt/β-catenin and PI3K/AKT pathways, essential for cell proliferation and hair-cycle changes. The study suggests limonin could be a potential treatment for hair loss.

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