MTOR Signaling in Hair Follicle and Hair Diseases: Recent Progress

    September 2023 in “ Frontiers in medicine ”
    Wei Tu, Yang Cao, Mei Sun … Heng-Guang Zhao
    Studysummary This review suggests that the mTOR signaling pathway may play a significant role in hair follicle health by influencing the effects of Vitamin D receptor deficiency, potentially contributing to hair follicle damage and related hair loss conditions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 55

    1. MTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation EMBO reports · 2023
    2. MiR-27a Targeting PIK3R3 Regulates the Proliferation and Apoptosis of Sheep Hair Follicle Stem Cells Animals · 2022
    3. Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells Nutrients · 2022
    4. Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata Frontiers in immunology · 2022
    5. The Regulation of Skin Homeostasis, Repair, and the Pathogenesis of Skin Diseases by Spatiotemporal Activation of Epidermal mTOR Signaling Frontiers in Cell and Developmental Biology · 2022
    6. Primary Cicatricial Alopecias Are Characterized by Dysregulation of Shared Gene Expression Pathways PNAS Nexus · 2022
    7. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    8. Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of GSK3β Activity in Cultured Human Dermal Papilla Cells Molecules · 2022
    9. Prevalence of Low Serum Vitamin D Levels in Patients Presenting With Androgenetic Alopecia: A Review Cureus · 2021
    10. Resident Human Dermal Gamma Delta T-Cells Operate as Stress Sentinels: Lessons from the Hair Follicle Journal of Autoimmunity · 2021
    11. Micro-Current Stimulation Has Potential Effects of Hair Growth Promotion on Human Hair Follicle-Derived Papilla Cells and Animal Model International Journal of Molecular Sciences · 2021
    12. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    13. Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata JCI insight · 2021
    14. Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells Biomolecules & therapeutics · 2021
    15. A Cross-Sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men Biological Trace Element Research · 2020
    16. Immunology of Alopecia Areata Central-European Journal of Immunology/Central European Journal of Immunology · 2020
    17. Pro-Inflammatory Vδ1+ T-Cells Infiltrates Are Present In And Around The Hair Bulbs Of Non-Lesional And Lesional Alopecia Areata Hair Follicles Journal of Dermatological Science · 2020
    18. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    19. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    20. Deficiency of Crif1 in Hair Follicle Stem Cells Retards Hair Growth Cycle in Adult Mice PloS one · 2020
    21. Serum 25-Hydroxyvitamin D Levels in Alopecia Areata, Female Pattern Hair Loss, and Male Androgenetic Alopecia in a Chinese Population Journal of Cosmetic Dermatology · 2020
    22. Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss Indian Journal of Dermatology · 2020
    23. PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology Experimental Dermatology · 2019
    24. Epidermal Mammalian Target of Rapamycin Complex 2 Controls Lipid Synthesis and Filaggrin Processing in Epidermal Barrier Formation Journal of Allergy and Clinical Immunology · 2019
    25. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    26. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    27. Pathomechanisms of Immune-Mediated Alopecia International Immunology · 2019
    28. Frontal Fibrosing Alopecia: An Update on the Hypothesis of Pathogenesis and Treatment International Journal of Women's Dermatology · 2019
    29. Differential Expression of Phospho-S6 in Hair Follicle Tumors: Evidence of Mammalian Target of Rapamycin Pathway Activation Journal of cutaneous pathology · 2019
    30. Eclipta Prostrata Promotes the Induction of Anagen, Sustains the Anagen Phase Through Regulation of FGF-7 and FGF-5 Pharmaceutical Biology · 2019
    31. Heat Stress Decreased Hair Follicle Population in Rex Rabbits Journal of animal physiology and animal nutrition · 2018
    32. Differential Expression of mTOR Signaling Pathway Proteins in Lichen Planopilaris and Frontal Fibrosing Alopecia Acta histochemica · 2018
    33. Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series Dermatologic therapy · 2018
    34. Serenoa Repens Extracts Promote Hair Regeneration and Repair of Hair Loss in Mouse Models by Activating TGF-β and Mitochondrial Signaling Pathway PubMed · 2018
    35. Vitamin D Status in Scarring and Nonscarring Alopecia Journal of The American Academy of Dermatology · 2018
    36. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    37. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    38. Correlation of Vitamin D and Vitamin D Receptor Expression in Patients with Alopecia Areata: A Clinical Paradigm International Journal of Dermatology · 2017
    39. The Role of Vitamin D in Non-Scarring Alopecia International Journal of Molecular Sciences · 2017
    40. Alopecia Areata: Current Situation and Perspectives Archivos Argentinos De Pediatria · 2017
    41. Activation of mTORC1 Signaling Is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017
    42. Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond? BioEssays · 2017
    43. DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization International journal of molecular sciences · 2016
    44. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    45. CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016
    46. Assessment of Vitamin D Receptors in Alopecia Areata and Androgenetic Alopecia Journal of Cosmetic Dermatology · 2016
    47. Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies Autoimmunity reviews · 2016
    48. Serum Vitamin D3 Level in Patients with Female Pattern Hair Loss International Journal of Trichology · 2016
    49. Epidemiology and Burden of Alopecia Areata: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2015
    50. Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro European Journal of Pharmacology · 2015
    51. mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration Journal of molecular cell biology/Journal of Molecular Cell Biology · 2015
    52. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    53. Vitamin D Deficiency in Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2014
    54. Serum Ferritin and Vitamin D in Female Hair Loss: Do They Play a Role? Skin Pharmacology and Physiology · 2013
    55. Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles Experimental dermatology · 2012