MTOR Signaling in Hair Follicle and Hair Diseases: Recent Progress

    September 2023 in “ Frontiers in medicine ”
    Wei Tu, Yang Cao, Mei Sun, Qian Liu, Heng-Guang Zhao
    Image of study
    TLDR The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.
    The document reviews the role of the mTOR signaling pathway in hair follicle biology and its connection to hair diseases such as alopecia areata, androgenetic alopecia, lichen planopilaris, and frontal fibrosing alopecia. It explains that mTORC1 and mTORC2 have distinct roles in hair follicle stem cell (HFSC) regulation, with mTORC1 promoting the anagen phase and mTORC2 maintaining HFSCs. The review also discusses the impact of autophagy, heat stress, and Vitamin D on mTOR signaling and hair growth, noting that dysregulation of this pathway can lead to hair loss. It suggests that targeting mTOR signaling could be a promising approach for developing new treatments for hair diseases, as it is a key component in hair follicle health and disease. The document also mentions the potential of JAK inhibitors and NRF2 activators in treating hair loss conditions and the need for further research on the interaction between mTOR and other pathways like BMP and Wnt.
    Discuss this study in the Community →

    Research cited in this study

    52 / 52 results

    Related Community Posts Join

    6 / 7 results

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community How uninformed the general public is about hair loss

      in Chat  318 upvotes 10 months ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

      community One full year progress on fin + min

      in Progress Pictures  517 upvotes 1 year ago
      A user shared their one-year progress using finasteride and minoxidil for hair loss, showing significant improvement. They also mentioned using the medication inconsistently and considering changes to their shampoo routine.

    Similar Research

    5 / 643 results