Resident Human Dermal Gamma Delta T-Cells Operate as Stress Sentinels: Lessons from the Hair Follicle

    August 2021 in “ Journal of Autoimmunity ”
    Youhei Uchida, Jennifer Gherardini, Karin I. Pappelbaum … Ralf Paus
    Studysummary This study found that human dermal γδT-cells can act as stress sentinels and potentially trigger autoimmune responses toward stressed hair follicles, resembling features of alopecia areata.
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    Research cited in this study 26

    1. Pro-Inflammatory Vδ1+ T-Cells Infiltrates Are Present In And Around The Hair Bulbs Of Non-Lesional And Lesional Alopecia Areata Hair Follicles Journal of Dermatological Science · 2020
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    8. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
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    10. Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse British journal of dermatology/British journal of dermatology, Supplement · 2016
    11. Laser Capture Microdissection Reveals Transcriptional Abnormalities In Alopecia Areata Before, During, And After Active Hair Loss Journal of Investigative Dermatology · 2015
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    21. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009
    22. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
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    Related research 5

    1. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    2. Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    4. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    5. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011