Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse

    Marta Bertolini, M. Pretzlaff, Mathias Sulk … Ralf Paus
    Studysummary This article reviews the role of vasoactive intestinal peptide in maintaining immune privilege in hair follicles and does not report new findings; the authors propose it as essential for immune homeostasis in alopecia areata.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on research.manchester.ac.uk →
    Discuss this study in the Community →

    Research cited in this study 7

    1. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    2. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    3. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    4. Can the Hair Follicle Become a Model for Studying Selected Aspects of Human Ocular Immune Privilege? Investigative Ophthalmology & Visual Science · 2011
    5. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    6. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    7. Spatial Relationship Between Merkel Cells and Langerhans Cells in Human Hair Follicles Journal of dermatological science · 2002

    Related research 4

    1. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    2. Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    4. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011